Cortical Spreading Depression Impairs Oxygen Delivery and Metabolism in Mice
نویسندگان
چکیده
منابع مشابه
Cortical spreading depression impairs oxygen delivery and metabolism in mice.
Cortical spreading depression (CSD) is associated with severe hypoperfusion in mice. Using minimally invasive multimodal optical imaging, we show that severe flow reductions during and after spreading depression are associated with a steep decline in cerebral metabolic rate of oxygen. Concurrent severe hemoglobin desaturation suggests that the oxygen metabolism becomes at least in part supply l...
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ژورنال
عنوان ژورنال: Journal of Cerebral Blood Flow & Metabolism
سال: 2011
ISSN: 0271-678X,1559-7016
DOI: 10.1038/jcbfm.2011.148